Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis
| Autor: | Huayun Li, Qing Wang, Hui-Bin Ma, Yun-Da Li, Yating Lv, Dong-Qiang Liu, Xi-Ze Jia, An-Feng Xiang |
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| Rok vydání: | 2020 |
| Předmět: |
Autism Spectrum Disorder
Cognitive Neuroscience Rest Precuneus behavioral disciplines and activities 050105 experimental psychology Angular gyrus 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine mental disorders Signed differential mapping Neural Pathways medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Prefrontal cortex Default mode network Brain Mapping Resting state fMRI 05 social sciences Brain Default Mode Network medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Neurology Autism spectrum disorder Autism Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain imaging and behavior. 15(5) |
| ISSN: | 1931-7565 |
| Popis: | Increasing evidence has shown that the resting state brain connectivity of default mode network (DMN) which are important for social cognition are disrupted in autism spectrum disorder (ASD). However, previous neuroimaging studies did not present consistent results. Therefore, we performed a meta-analysis of resting-state functional connectivity (rsFC) studies of DMN in the individuals with ASD and healthy controls (HCs) to provide a new perspective for investigating the pathophysiology of ASD. We carried out a search using the terms: ("ASD" OR "Autism") AND ("resting state" OR "rest") AND ("DMN" OR "default mode network") in PubMed, Web of Science and Embase to identify the researches published before January 2020. Ten resting state datasets including 203 patients and 208 HCs were included. Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method was applied to identify group differences. In comparison with the HCs, the patients with ASD showed increased connectivity in cerebellum, right middle temporal gyrus, superior occipital gyrus, right supramarginal gyrus, supplementary motor area and putamen. Decreased connectivity was discovered in some nodes of DMN, such as medial prefrontal cortex, precuneus and angular gyrus. These results may help us to further clarify the neurobiological mechanisms in patients with ASD. |
| Databáze: | OpenAIRE |
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