Influence of New Synthetic Xanthones on the Proliferation and Migration Potential of Cancer Cell Lines in Vitro
| Autor: | Sabina Gałka, Daniel Sypniewski, Paulina Borzdziłowska, Ilona Bednarek, Natalia Szkaradek, Henryk Marona, Dorota Żelaszczyk |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Cell Survival Xanthones Antineoplastic Agents Apoptosis HeLa Inhibitory Concentration 50 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Cell Line Tumor Xanthone medicine Humans Cytotoxicity Cell Proliferation 030304 developmental biology Pharmacology 0303 health sciences Molecular Structure biology Cancer biology.organism_classification medicine.disease Hep G2 Matrix Metalloproteinase 9 chemistry 030220 oncology & carcinogenesis Cancer cell Cancer research Matrix Metalloproteinase 2 Molecular Medicine Ovarian cancer Liver cancer |
| Popis: | Background: Natural plant metabolites and their semisynthetic derivatives have been used for years in cancer therapy. Xanthones are oxygenated heterocyclic compounds produced as secondary metabolites by higher plants, fungi or lichens. Xanthone core may serve as a template in the synthesis of many derivatives that have broad biological activities. Objective: This study synthesized a series of 17 new xanthones, and their anticancer potential was also evaluated. Methods: The anticancer potential was evaluated in vitro using a highly invasive T24 cancer cell line. Direct cytotoxic effects of the xanthones were established by IC50 estimation based on XTT assay. Results: 5 compounds of the total 17 showed significant cytotoxicity toward the studied cancer cultures and were submitted to further detailed analysis, including studies examining their influence on gelatinase A and B expression, as well as on the cancer cells migration and adhesion to an extracellular matrix. These analyses were carried out on five human tumor cell lines: A2780 (ovarian cancer), A549 (lung cancer), HeLa (cervical cancer), Hep G2 (liver cancer), and T24 (urinary bladder cancer). All the compounds, especially 4, showed promising anticancer activity: they exhibited significant cytotoxicity towards all the evaluated cell lines, including MCF-7 breast cancer, and hindered migration-motility activity of cancer cells demonstrating more potent activity than α-mangostin which served as a reference xanthone. Conclusion: These results suggest that our xanthone derivatives may be further analyzed in order to include them in cancer treatment protocols. |
| Databáze: | OpenAIRE |
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