T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
| Autor: | Jin-Xiong She, Paul Minh Huy Tran, John C. Reed, bin Satter Khaled, John C. Morgan, Sharad Purohit, Bruce W. Bode, Jennifer Bryant, Melissa Gardiner, Diane Hopkins, Lynn Kim Hoang Tran, Eileen Kim, Risa Bernard |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
complications type 1 diabetes Health Toxicology and Mutagenesis Article Nephropathy risk prediction Diabetic Neuropathies Risk Factors Internal medicine retinopathy medicine Humans Type 1 diabetes Diabetic Retinopathy business.industry Public Health Environmental and Occupational Health medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Peripheral neuropathy Blood pressure Diabetes Mellitus Type 2 peripheral and autonomic neuropathy Cohort nephropathy Medicine clinical calculator Autonomic neuropathy business Clinical risk factor Retinopathy |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 11094, p 11094 (2021) International Journal of Environmental Research and Public Health Volume 18 Issue 21 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN, respectively. This tool was built to help inform patients of their current risk of microvascular complications and to motivate patients to control their HbA1c and systolic blood pressure in order to reduce their risk of these complications. |
| Databáze: | OpenAIRE |
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