Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer–Schuster Rearrangement
| Autor: | Xiang-Yu Zhang, Xin-Yuan Liu, Ya-Ping Xiong, Lin Huang, Mingyue Wu, Li-Jiao Zhao, Bin Tan, Can-Liang Ma |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Trifluoromethyl
Alkylation Hydrocarbons Fluorinated Molecular Structure Trifluoromethylation Organic Chemistry Stereoisomerism Meyer–Schuster rearrangement Biochemistry Catalysis Domino chemistry.chemical_compound chemistry Heterocyclic Compounds Reagent Copper catalyzed Organic chemistry Rearrangement reaction Physical and Theoretical Chemistry Enone Copper |
| Zdroj: | Organic Letters. 16:1000-1003 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol403741m |
| Popis: | A novel domino copper-catalyzed trifluoromethylated Meyer-Schuster rearrangement reaction with Togni's reagent was developed, leading to α-trifluormethyl (CF3) enone products with moderate to good yields. Furthermore, α-CF3 enones can be transformed toward important trifluoromethyl heterocyclic motifs in a one-pot version. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|