Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation
| Autor: | Oleg Melnyk, Soizic Besret, Nathalie Ollivier, Patricia Melnyk |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Bioconjugation Peptidomimetic Organic Chemistry Phenylcarbamates Biomedical Engineering Phenylthiocarbamate Pharmaceutical Science Bioengineering Peptide Chemistry Techniques Synthetic Review Combinatorial chemistry chemistry.chemical_compound chemistry Thiocarbamates Peptide synthesis Peptidomimetics Sulfhydryl Compounds Peptides Biotechnology |
| Zdroj: | Bioconjugate Chemistry |
| ISSN: | 1520-4812 1043-1802 |
| DOI: | 10.1021/bc500052r |
| Popis: | The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and peptide bioconjugation during the last 10 years. The aim of this review is to provide an overview of this emerging field. |
| Databáze: | OpenAIRE |
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