Increased Micronucleus Frequency After Oral Administration of Cadmium in Dogs
| Autor: | Nefise Imamoglu, Halil Demirtas, Narin Liman, Hamiyet Donmez-Altuntas, Zuhal Hamurcu |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Group ii Administration Oral chemistry.chemical_element Body weight Biochemistry Inorganic Chemistry chemistry.chemical_compound Dogs Oral administration Internal medicine Cadmium Compounds medicine Animals Micronuclei Chromosome-Defective Carcinogen Cadmium Micronucleus Tests Chemistry Biochemistry (medical) Oxides General Medicine Endocrinology Models Animal Immunology Cadmium oxide Female Micronucleus DNA Damage International agency |
| Zdroj: | Biological Trace Element Research. 112:241-246 |
| ISSN: | 0163-4984 |
| DOI: | 10.1385/bter:112:3:241 |
| Popis: | Cadmium (Cd) is a toxic heavy metal that has been classified as a human carcinogen by the International Agency for Research on Cancer. The genotoxic effects of cadmium oxide (CdO) were investigated in cultured dog lymphocytes after a short-term oral CdO administration by the micronucleus (MN) test. The dogs were given 10 mg CdO/kg body weight per day for 3 and 28 d, respectively group I (n = 7) and group II (n = 6). Blood samples were collected at the beginning of feeding and at 4 and 29 d after Cd administration and cultured for 72 h. Whereas no significant increase in the MN frequency in group I was observed (p = 0.398), a significant MN induction with CdO was found in group II (p = 0.028) when compared with initial MN frequencies of dogs in both groups. Our results suggest that CdO might be directly and/or indirectly genotoxic after a monthly oral administration of CdO in dogs. |
| Databáze: | OpenAIRE |
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