Enhancement of opsonophagocytosis of Bacteroides spp. by clindamycin in subinhibitory concentrations
| Autor: | D. W. Lambe, Donald A. Ferguson, Jan Verhoef, E. M. Veringa |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Microbiology (medical)
Neutrophils Phagocytosis In Vitro Techniques Microbiology medicine Bacteroides Humans Pharmacology (medical) Bacteroidaceae Pharmacology biology Clindamycin food and beverages Complement System Proteins Opsonin Proteins biology.organism_classification Antibodies Bacterial Antibody opsonization Microscopy Electron Infectious Diseases Bacteroides fragilis Bacteroides thetaiotaomicron Bacteria medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 23:577-587 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Radioactively labelled bacteria were incubated overnight in the presence or absence of one-half the MIC of clindamycin, then preopsonized with normal human serum or homologous rabbit antiserum and incubated with human polymorphonuclear leucocytes. Clindamycin in subinhibitory concentrations significantly enhanced the phagocytosis of all four Bacteroides strains. Complement-dependent as well as antibody-dependent phagocytosis was enhanced by clindamycin in one Bacteroides strain. In the other three strains, only antibody dependent phagocytosis was enhanced by clindamycin. Transmission electron microscopy confirmed phagocytosis of the bacteroides. |
| Databáze: | OpenAIRE |
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