Supplementary Methods, Figures 1 - 6, Tables 1 - 5 from Identification of a Tumor-Suppressive Human-Specific MicroRNA within the FHIT Tumor-Suppressor Gene

Autor: Ya Wang, Walter J. Curran, Wuju Li, Xiaofei Zheng, Chenguang Wang, Xiang Wang, Shuofeng Hu, Wooi Loon Ng, Hongyan Wang, Yazhuo Li, Po Zhao, Fang Yu, Jipo Sheng, I. King Jordan, Jittima Piriyapongsa, Jian Wang, Xiaomin Ying, Baocheng Hu
Rok vydání: 2023
DOI: 10.1158/0008-5472.22400802
Popis: PDF file - 858KB, Supplementary Methods, Supplementary References, Figure S1-6, Table S1-5. Figure S1. Identification of a new miR in FHIT intron. Figure S2. The SNP variant around the Pri-C2-miR region in FHIT did not affect the C2-miR expression. Figure S3. C2-miR and FHIT are under the same transcriptional control. Figure S4. C2-miR inhibiting human tumor cell growth was not through promoting apoptosis. Figure S5. C2-miR inhibits human tumor cell growth through targeting CCND1, ERBB2, DNMT3A or DNMT3B. Figure S6. Multiple members of the miR-548 family could target the same oncogenes. Table S1. The documented miR-548 family members. Table S2. Quantities of FHIT or C2-miR in total cell RNA (20 ng). Table S3. Expression comparison of pri-miRs or mature miRs in 293FT cells. Table S4. Primers used in this study. Table S5. NanoString probes for detecting 29 members of the miR-548 family.
Databáze: OpenAIRE