Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
| Autor: | Stanley E. Lazic, Helen E Grote, Colin Blakemore, Roger A. Barker, A. Jennifer Morton, Anthony J. Hannan, Anna O. G. Goodman, Anton van Dellen |
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| Rok vydání: | 2007 |
| Předmět: |
Olfactory system
Doublecortin Domain Proteins Male Doublecortin Protein Central nervous system Hippocampus Mice Transgenic Nerve Tissue Proteins Neural Cell Adhesion Molecule L1 Olfaction Biology Statistics Nonparametric Primary olfactory cortex Mice Olfaction Disorders Discrimination Psychological Cortex (anatomy) Piriform cortex medicine Animals Humans Molecular Biology Huntingtin Protein Neocortex Neuronal Plasticity General Neuroscience Neuropeptides Nuclear Proteins Olfactory Pathways Middle Aged Disease Models Animal medicine.anatomical_structure Huntington Disease nervous system Case-Control Studies Mice Inbred CBA Sialic Acids Female Neurology (clinical) Neuroscience Microtubule-Associated Proteins psychological phenomena and processes Developmental Biology |
| Zdroj: | Brain research. 1151 |
| ISSN: | 0006-8993 |
| Popis: | Reduced neuronal plasticity in the striatum, hippocampus, and neocortex is a common feature of transgenic mouse models of Huntington's disease (HD). Doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) are associated with structural plasticity in the adult mammalian brain, are markers of newly formed neurons in the dentate gyrus of the adult hippocampus, and are highly expressed in primary olfactory (piriform) cortex. Animal studies have demonstrated that a reduction in plasticity in the piriform cortex is associated with a selective impairment in odour discrimination. Therefore, the number of DCX and PSA-NCAM immunoreactive cells in the piriform cortex were quantified as measures of plasticity in early stage (fifteen week old) R6/1 transgenic HD mice. The transgenic mice had a large reduction in the number of DCX and PSA-NCAM immunoreactive cells in the piriform cortex, similar to that previously reported in the R6/2 mice. We also tested whether odour discrimination, as well as identification and detection, were impaired in HD patients and found that patients (at a similar disease stage as the mice) had an impairment in odour discrimination and identification, but not odour detection. These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex. |
| Databáze: | OpenAIRE |
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