Antarctic environments as a source of bacterial and fungal therapeutic enzymes

Autor: IGOR G.O. LIMA, JAMES R.S. BISPO, ADSON Y.H. AGOSTINHO, ALINE C. DE QUEIROZ, MAGNA SUZANA A. MOREIRA, MICHEL RODRIGO Z. PASSARINI, VALÉRIA M. DE OLIVEIRA, LARA D. SETTE, LUIZ HENRIQUE ROSA, ALYSSON WAGNER F. DUARTE
Přispěvatelé: Complexo de Ciências Médicas e Enfermagem, Instituto de Ciências Biológicas e da Saúde, Universidade Federal da Integração Latino-Americana, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (UNESP), Universidade Federal de Minas Gerais (UFMG)
Rok vydání: 2022
Předmět:
Zdroj: Anais da Academia Brasileira de Ciências v.94 suppl.1 2022
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC
Anais da Academia Brasileira de Ciências, Volume: 94 Supplement 1, Article number: e20210452, Published: 11 FEB 2022
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1678-2690
0001-3765
DOI: 10.1590/0001-3765202220210452
Popis: Made available in DSpace on 2022-04-28T19:50:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms. Universidade Federal de Alagoas Complexo de Ciências Médicas e Enfermagem, Campus Arapiraca, Av. Manoel Severino Barbosa, s/n, Bom Sucesso Universidade Federal de Alagoas Instituto de Ciências Biológicas e da Saúde, Av. Lourival Melo Mota, s/n, Tabuleiro do Martins Universidade Federal da Integração Latino-Americana, Av. Silvio Américo Sasdelli, 1842, Itaipú A Universidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrárias, R. Alexandre Cazellato, 999, Betel Departamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela Vista Universidade Federal de Minas Gerais Instituto de Ciências Biológicas, Av. Presidente Antônio Carlos, 6627, Pampulha Departamento de Biologia Geral e Aplicada Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho, Av. 24 A, 1515, Bela Vista
Databáze: OpenAIRE
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