Prognostic significance of ANO1 expression in cancers
| Autor: | Haini Li, Congxiao Zhang, Jing Gao, Zongtao Liu, Xiaoqing Cui, Shengmei Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Colorectal cancer Estrogen receptor Gene Expression ANO1 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Neoplasms medicine Humans cancer 030212 general & internal medicine Anoctamin-1 Proportional Hazards Models Proportional hazards model business.industry Hazard ratio Cancer General Medicine Odds ratio medicine.disease Head and neck squamous-cell carcinoma Neoplasm Proteins 030220 oncology & carcinogenesis Female prognosis meta-analyze business Biomarkers Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of ANO1 in cancers. Methods: A total of 1760 patients from 7 eligible studies were included into the analysis. Pooled hazard ratios or odds ratios were extracted and calculated with a random-effects model, and analyses of heterogeneity bias were conducted. Results: Our results showed that over expression of ANO1 was significantly correlated with poor overall survival in all cancers (HR = 1.52; 95% CI: 1.19–1.92; P = .0006). Subgroup analysis indicated that there was a significant association between over expression of ANO1 and poor prognosis breast cancer (HR = 3.24; 95% CI: 1.74–6.04), head and neck squamous cell carcinoma (HR = 1.14; 95% CI: 1.00–1.30), esophageal squamous cell carcinoma (HR = 1.93; 95% CI: 1.07–3.50), gastric cancer (HR = 1.62; 95% CI: 1.12–2.34) and colorectal cancer (HR = 1.38; 95% CI: 1.03–1.85). In addition, over expression of ANO1 was not associated with TNM stage, histological grade, lymph node metastasis, tumor size, age and gender. However, ANO1 was significantly associated with human epidermal growth factor receptor 2, but not associated with progesterone receptor or estrogen receptor in breast cancer. Conclusions: Our results indicate that ANO1 can be a predictive factor for prognosis of cancer. |
| Databáze: | OpenAIRE |
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