Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk
| Autor: | Younghoon Kim, Dong June Park, Sangnam Oh, Bohyun Yun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Veterinary (miscellaneous) Short Communication Biology SF1-1100 Biochemistry Genetics and Molecular Biology (miscellaneous) Exosome 03 medical and health sciences Biological condition 0302 clinical medicine fluids and secretions Functional importance microRNA Mature milk Genetics Mammals Ecology Colostrum RNA food and beverages MicroRNA Microvesicles Animal culture 030104 developmental biology 030220 oncology & carcinogenesis Animal Science and Zoology Dietary exosome Food Science |
| Zdroj: | Journal of Animal Science and Technology Journal of Animal Science and Technology, Vol 63, Iss 3, Pp 593-602 (2021) |
| ISSN: | 2055-0391 2672-0191 |
| Popis: | Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and functional importance of milk-derived miRNAs are still undetermined. This study applied RNA sequencing to explore the featured profiles of miRNA expression in colostrum and mature milk-originated exosomes from human, bovine, and caprine milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine and caprine milk. Interestingly, abundant miRNAs expressed in human milk are similarly conserved across species. In addition, we confirmed that immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed in the colostrum and mature milk of cows and caprines as well as humans. Our results provide new insights and resources for investigating the functionality of immune-associated miRNAs and evaluating physiological and biological condition in human, bovine and caprine milk as biomarkers. |
| Databáze: | OpenAIRE |
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