Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability?
| Autor: | Taner Sezer, Füsun Alehan, Oya Balci, Nilufer Bayraktar, Figen Özçay |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Screening test Duodenum Tissue transglutaminase Duodenal biopsy Prevalence Enzyme-Linked Immunosorbent Assay Disease 03 medical and health sciences 0302 clinical medicine Intellectual Disability 030225 pediatrics Healthy control Intellectual disability Humans Medicine Child biology business.industry medicine.disease Immunoglobulin A Celiac Disease Pediatrics Perinatology and Child Health Etiology biology.protein Physical therapy Female Neurology (clinical) business Biomarkers Blood Chemical Analysis 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Neurology. 31:285-288 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073815589759 |
| Popis: | To determine the prevalence of celiac disease in children and adolescents with nonsyndromic intellectual disability, we investigated serum levels of tissue transglutaminase antibody and total IgA from 232 children with nonsyndromic intellectual disability and in a healthy control group of 239 children. Study participants who were positive for tissue transglutaminase antibody underwent a duodenal biopsy. A total of 3 patients in the nonsyndromic intellectual disability group (5.45%) and 1 in the control group (0.41%) had positive serum tissue transglutaminase antibody (P > .05). Duodenal biopsy confirmed celiac disease in only 1 patient who had nonsyndromic intellectual disability. In this present study, children with nonsyndromic intellectual disability did not exhibit a higher celiac disease prevalence rate compared with healthy controls. Therefore, we suggest that screening test for celiac disease should not be necessary as a part of the management of mild and moderate nonsyndromic intellectual disability. However, cases of severe nonsyndromic intellectual disability could be examined for celiac disease. |
| Databáze: | OpenAIRE |
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