Site‐Selective Ser‐Hydrolase Labelling with a Luminescent Organometallic NCN–Platinum Complex

Autor:	Wieczorek, B., Lemcke, B., Dijkstra, H.P., Egmond, M.R., Klein Gebbink, R.J.M., van Koten, G., Membrane Enzymology, Organic Chemistry and Catalysis, Sub Chem Biol & Organic Chem begr 1-6-12, Dep Scheikunde, Sub Membrane Enzymology begr. 01-06-12
Rok vydání:	2010
Předmět:	Gel electrophoresis chemistry.chemical_element Serine hydrolase Phosphonate Combinatorial chemistry Inorganic Chemistry Absorbance chemistry.chemical_compound chemistry Hydrolase Click chemistry Organic chemistry Luminescence Platinum
Zdroj:	European Journal of Inorganic Chemistry, 13, 1929. Wiley-VCH Verlag
ISSN:	1099-0682 1434-1948
DOI:	10.1002/ejic.200900980
Popis:	The synthesis, spectroscopic properties and protein-binding studies of a novel luminescent organometallic NCN-platinum complex are described. The luminescent organometallic complex was linked to a serine hydrolase reactive phosphonate group by means of click chemistry, and was ex-plotted in serine hydrolase specific-binding studies using gel electrophoresis. The NCN-platinum protein label was found to be a robust dye with absorbance and emission maxima between 374-380 and 482-493 nm, respectively, and quantum, yields between 0.04 and 0.15
Databáze:	OpenAIRE
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