Peginterferon/ribavirin treatment achieves a higher compliance rate than interferon/ribavirin combination in patients chronically infected with HCV on methadone maintenance
| Autor: | Dimitrios Xinopoulos, Dimitrios Tzourmakliotis, Emmanouel Paraskevas, Domna Tsaklakidou, Dimitrios Dimitroulopoulos, Klisthenis Tsamakidis, Olga Anagnostou, Elefteria Petroulaki, Spilios Manolakopoulos |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Methadone maintenance medicine.medical_specialty Hepatitis C virus Alpha interferon Interferon alpha-2 Pharmacology medicine.disease_cause Antiviral Agents Gastroenterology Polyethylene Glycols chemistry.chemical_compound Interferon Pegylated interferon Internal medicine Ribavirin Opiate Substitution Treatment medicine Humans Substance Abuse Intravenous Interferon alfa Hepatology business.industry Interferon-alpha Hepatitis C Hepatitis C Chronic medicine.disease Antidepressive Agents Drug Utilization Recombinant Proteins Treatment Outcome chemistry Patient Compliance Drug Therapy Combination Female business Methadone Follow-Up Studies medicine.drug |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 21:1407-1412 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0b013e3283110198 |
| Popis: | INTRODUCTION Chronic hepatitis C virus infection (HCV) is the most common infectious disease among intravenous drug users. AIMS To determine and compare compliance rates between two groups of chronic HCV patients from the methadone substitution program of the National Greek Organization Against Drugs treated with either pegylated interferon alpha-2b/ribavirin or with interferon alpha-2b/ribavirin during 48 weeks of therapy and 24 weeks of follow-up. Furthermore, to evaluate the efficacy of each treatment modality. METHODS Forty-five consecutive methadone maintenance (MM) patients (group A, 36 males, nine females) were treated with pegylated interferon alpha-2b (weight-based dosing 1.5 microg/kg/week) and ribavirin 1000-1200 mg/day orally. Sixty-five consecutive MM patients (group B, 52 males, 13 females) were treated with interferon alpha-2b (6 MIU, three times/week) and ribavirin with the doses reported above. During the study, all patients were followed up periodically by hepatologists, internists, and psychiatrists. RESULTS Baseline characteristics were similar between the two groups. Thirty-four out of 45 patients (75.6%) from group A and 31 of 65 patients (47.7%) from group B completed therapy (P =0.006). Thirty-two (71.1%) patients from group A and 27 patients (41.5%) from group B were followed-up until the end of week 72 (P = 0.004). At the end of the follow-up, sustained virologic response was achieved in 23 of 45 (51.1%) patients from group A and 21 of 65 patients (32.3%) from group B (P =0.075). CONCLUSION Pegylated interferon alpha-2b/ribavirin treatment achieved a significantly higher compliance rate than interferon alpha-2b/ribavirin in MM patients with chronic HCV infection. After 24 weeks of follow-up, response rates were similar for patients who were compliant to treatment for both groups. |
| Databáze: | OpenAIRE |
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