B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production
| Autor: | Shaun W. Jackson, Nikita S. Kolhatkar, David J. Rawlings |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
T cell
Immunology Antigen presentation Autoimmunity Biology Article Autoimmune Diseases Immune tolerance Immune Tolerance medicine Animals Humans Immunology and Allergy Antigen-presenting cell B cell Autoantibodies Antigen Presentation B-Lymphocytes CD40 Autoantibody Germinal center Germinal Center medicine.anatomical_structure biology.protein Cytokines Signal Transduction |
| Zdroj: | Current Opinion in Immunology. 33:70-77 |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2015.01.018 |
| Popis: | A significant proportion of autoimmune-associated genetic variants are expressed in B cells, suggesting that B cells may play multiple roles in autoimmune pathogenesis. In this review, we highlight recent studies demonstrating that even modest alterations in B cell signaling are sufficient to promote autoimmunity. First, we describe several examples of genetic variations promoting B cell-intrinsic initiation of autoimmune germinal centers and autoantibody production. We highlight how dual antigen receptor/toll-like receptor signals greatly facilitate this process and how activated, self-reactive B cells may function as antigen presenting cells, leading to loss of T cell tolerance. Further, we propose that B cell-derived cytokines may initiate and/or sustain autoimmune germinal centers, likely also contributing, in parallel, to programing of self-reactive T cells. |
| Databáze: | OpenAIRE |
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