Damage to the Testicular Structure of Rats by Acute Oral Exposure of Cadmium
| Autor: | Tong Chen, Maosheng Cao, Zijiao Zhao, Chunjin Li, Yun Zhao, Tariq Iqbal, Xu Zhou, Lu Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty DNA damage cadmium Health Toxicology and Mutagenesis Lumen (anatomy) daily sperm production 010501 environmental sciences Biology 01 natural sciences Article Rats Sprague-Dawley Andrology 03 medical and health sciences Interstitial space Testis medicine Animals 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Public Health Environmental and Occupational Health Spermatozoa Sperm spermatogenesis Rats Comet assay Medicine Histopathology medicine.symptom Spermatogenesis Weight gain industrial toxicology |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 6038, p 6038 (2021) Volume 18 Issue 11 |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Cadmium (Cd) is one of the most important heavy metal toxicants, used throughout the world at the industrial level. It affects humans through environmental and occupational exposure and animals through the environment. The most severe effects of oral exposure to Cd on the male reproductive system, particularly spermatogenesis, have not been discussed. In this study, we observed the damage to the testes and heritable DNA caused by oral exposure to Cd. Adult male Sprague–Dawley rats were divided into four groups: a control group and three groups treated with 5, 10, and 15 mg Cd/kg/day for 17 days by oral gavage. Our results revealed that Cd significantly decreases weight gain in 10 and 15 mg/kg groups, whereas the 5 mg/kg groups showed no difference in weight gain. The histopathology showed adverse structural effects on the rat testis by significantly reducing the thickness of the tunica albuginea, the diameter of the tubular lumen, and the interstitial space among seminiferous tubules and increasing the height of the epithelium and the diameter of the seminiferous tubules in Cd treated groups. Comet assay in epididymal sperms demonstrated a significant difference in the lengths of the head and comet in all the 3 Cd treated groups, indicating damage in heritable DNA, although variations in daily sperm production were not significant. Only a slight decrease in sperm count was reported in Cd-treated groups as compared to the control group, whereas the tail length, percentage of DNA in head, and tail showed no significant difference in control and all the experimental groups. Overall, our findings indicate that Cd toxicity must be controlled using natural sources, such as herbal medicine or bioremediation, with non-edible plants, because it could considerably affect heritable DNA and induce damage to the reproductive system. |
| Databáze: | OpenAIRE |
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