Vitamin A deficiency during pregnancy of HIV infected and non-infected women in tropical settings of Northwest Ethiopia
| Autor: | Masayo Nakamori, Birhanemeskel Tegene, Gashaw Yitayaw, Fusao Ota, Andargachew Mulu, Afework Kassu, Nguyen Van Nhien, Kahsay Huruy, Assegedech Bekele, Shigeru Yamamoto, Yared Wondimhun |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Vitamin medicine.medical_specialty Adolescent Cross-sectional study HIV Infections Young Adult chemistry.chemical_compound Epidemiology medicine Humans Young adult Pregnancy Anthropometry Vitamin A Deficiency Obstetrics business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Middle Aged HIV infection Ascorbic acid medicine.disease Pregnancy Complications Vitamin A deficiency Cross-Sectional Studies chemistry Immunology HIV-1 Female Vitamin A deficiencies pregnancy Ethiopia Multivitamin business Research Article |
| Zdroj: | BMC Public Health, Vol 11, Iss 1, p 569 (2011) BMC Public Health |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/1471-2458-11-569 |
| Popis: | Background Vitamin A deficiency (VAD) is known to be a major public health problem among women of reproductive age in South East Asia and Africa. In Ethiopia, there are no studies conducted on serum vitamin A status of HIV-infected pregnant women. Therefore, the present study was aimed at determining the level of serum vitamin A and VAD among pregnant women with and without HIV infection in tropical settings of Northwest Ethiopia. Methods In this cross-sectional study, blood samples were collected from 423 pregnant women and from 55 healthy volunteers who visited the University of Gondar Hospital. Serum concentration of vitamin A was measured by high performance liquid chromatography. Results After controlling for total serum protein, albumin and demographic variables, the mean ± SD serum vitamin A in HIV seropositive pregnant women (0.96 ± 0.42 μmol/L) was significantly lower than that in pregnant women without HIV infection (1.10 ± 0.45 μmol/L, P < 0.05). Likewise, the level of serum vitamin A in HIV seropositive non-pregnant women (0.74 ± 0.39) was significantly lower than that in HIV negative non-pregnant women (1.18 ± 0.59 μmol/L, P < 0.004). VAD (serum retinol < 0.7 μmol/L) was observed in 18.4% and 17.7% of HIV infected and uninfected pregnant women, respectively. Forty six percent of non-pregnant women with HIV infection had VAD while only 28% controls were deficient for vitamin A (P = 0.002). Conclusion The present study shows that VAD is a major public health problem among pregnant women in the tropical settings of Northwest Ethiopia. Considering the possible implications of VAD during pregnancy, we recommend multivitamin (which has a lower level of vitamin A) supplementation in the care and management of pregnant women with or without HIV infection. |
| Databáze: | OpenAIRE |
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