AUGMENTATION OF ACTH-RELEASING ACTIVITY OP SYNTHETIC CORTICOTROPIN RELEASING FACTOR (CRF) BY VASOPRESSIN IN WOMEN
| Autor: | K. N. Muse, P. Contreras, S. S. C. Yen, Daniel Gibbs, Jun Liu, Wylie Vale, Jean Rivier |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Vasopressin Hydrocortisone Corticotropin-Releasing Hormone Vasopressins Chemistry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Drug Synergism Biochemistry Kinetics Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 57:1087-1089 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-57-5-1087 |
| Popis: | In order to study the interaction between vasopressin (VP) and hypothalamic corticotropin releasing factor (CRF) on the release of ACTH, VP and CRF were administered separately and in combination to normal cycling women. The combined hormones raised plasma ACTH levels higher than the sum of the separate responses and 5 times more than CRF alone. This study reveals for the first time synergism between VP and CRF in their ACTH releasing effects in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|