Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers
| Autor: | Amit Sharma, Carol Sargeant, R. Todd Stravitz, Carolyn Driscoll, M. Shadab Siddiqui, Velimir A. Luketic, M. Bilal Siddiqui, Richard K. Sterling, Ravi Chhatrala, Puneet Puri, Scott Matherly, Arun J. Sanyal |
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| Rok vydání: | 2015 |
| Předmět: |
Liver Cirrhosis
Male Risk medicine.medical_specialty Very low-density lipoprotein Cirrhosis Apolipoprotein B Lipoproteins medicine.medical_treatment Liver transplantation Tacrolimus Body Mass Index Internal medicine Diabetes mellitus medicine Humans Prospective Studies Aged Immunosuppression Therapy Inflammation Transplantation Hepatology biology business.industry Cholesterol HDL Cholesterol LDL Middle Aged Atherosclerosis medicine.disease Transplant Recipients Liver Transplantation Cross-Sectional Studies Endocrinology Cyclosporine biology.protein Female lipids (amino acids peptides and proteins) Surgery business Body mass index Biomarkers Liver Failure Dyslipidemia Lipoprotein |
| Zdroj: | Liver Transplantation. 21:623-630 |
| ISSN: | 1527-6473 1527-6465 |
| DOI: | 10.1002/lt.24100 |
| Popis: | Although cardiovascular disease (CVD) is the leading cause of long-term mortality in liver transplant recipients (LTRs), the role of recently identified biomarkers of CVD risk in liver transplantation is unknown. We aimed to evaluate an extensive CVD risk profile in LTRs. Markers of CVD risk in 65 LTRs with no known history of diabetes mellitus (DM), dyslipidemia, or ischemic heart disease were compared to age-, sex-, and body mass index (BMI)–matched controls with no chronic medical disease. LTRs on corticosteroids or those with graft cirrhosis (GC) were excluded. The effect of calcineurin inhibitors on the CVD risk profile was separately analyzed in LTRs receiving either tacrolimus (Tac) or cyclosporine A (CsA). To evaluate the impact of GC, a comparison was made between LTRs with and without GC. Non-DM LTRs were matched to controls with respect to age, sex, and BMI. LTRs had similar serum high-density lipoprotein–cholesterol (HDL-C), low-density lipoprotein–cholesterol (LDL-C), and total cholesterol in comparison with BMI-matched controls. Proatherogenic small-dense (sd) LDL-C (33.6 ± 14 versus 25.9 ± 9.9 mg/dL; P |
| Databáze: | OpenAIRE |
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