Changes of peripheral lymphocyte subsets and cytokine environment during aging and deteriorating gastrointestinal tract health status
| Autor: | Jing Wu, Guodong Yang, Min Fang, Yongchao Ma, Kuiliang Liu, Dongfang Wang, Jing Wang, Hong Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chemokine medicine.medical_treatment T cell T cells Disease NK cells 03 medical and health sciences Research Paper: Gerotarget (Focus on Aging) medicine Gastrointestinal tract biology gastrointestinal tract disease business.industry Gerotarget aging Natural killer T cell NKG2D NKT cells 030104 developmental biology Cytokine medicine.anatomical_structure Oncology Immunology biology.protein business CD8 |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Human immune senescence accompanies with the physical and physiological frailty. The functional change and shift of NK, NKT and T cell subsets by aging have been widely studied. However, it remains largely unclear how the aging and disease conditions affect the distribution of lymphocytes. In the present study, 233 subjects with age range from 20 to 87 year old, including healthy people, people with chronic gastrointestinal tract disease or cancers were investigated. We found that the proportion of NK cells, CD8+ T cells and NKT cells remained relatively unchanged with aging. However, NKG2D and CD16 expression level on NK cells decreased with aging indicating impaired NK cell function. Surprisingly, the proportion of NK, NKT and T cells all declined with deteriorating health status from health to chronic gastrointestinal tract disease and cancer. Furthermore, cytokine and chemokine profiles changed with aging, but did not vary with different health status. Our results highlight new evidence for a continuum of change during immunologic aging and show unique data for variations of NK cells, CD8+ T cells, NKT cells, and cytokine microenvironment with human aging and health status transformation. |
| Databáze: | OpenAIRE |
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