Enantioselective formal [3+2]-cycloadditions to access spirooxindoles bearing four contiguous stereocenters through synergistic catalysis

Autor:	Wei Su, Xiu-Liang Cheng, Hai Peng, Hua Yang, Jun-An Xiao, Wen-Qiang Chen, Yan-Min Huang, Jin-Lian Li, Kai Chen
Rok vydání:	2021
Předmět:	Metals and Alloys Enantioselective synthesis chemistry.chemical_element General Chemistry Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Stereocenter chemistry Materials Chemistry Ceramics and Composites Synergistic catalysis Palladium
Zdroj:	Chemical Communications. 57:4456-4459
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d0cc07957j
Popis:	An enantioselective ring-opening formal [3+2]-cycloaddition of spirovinylcyclopropyl oxindoles with enals via synergistic catalysis of palladium(0) and a chiral organocatalyst has been developed, affording spirooxindoles bearing four contiguous stereocenters in good yields with excellent enantioselectivities. The generality and utility of the protocol were also demonstrated through scale-up experiments and synthetic transformation of the resulting cycloadduct.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8835f918962720f1d6d8cf36c0f043 https://doi.org/10.1039/d0cc07957j Zobrazit plný text záznamu