The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery

Autor: M. Leentjens, P. F. N. Bosschieter, Abdulmohsen Al-Terki, C. A. L. de Raaff, C. E. E. de Vries, Maha Hammad, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Mohamed Abu-Farha, N. de Vries, Jehad Abubaker
Přispěvatelé: Oral Kinesiology, Surgery, APH - Health Behaviors & Chronic Diseases, Plastic, Reconstructive and Hand Surgery
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Leentjens, M, Bosschieter, P F N, Al-Terki, A, de Raaff, C A L, de Vries, C E E, Hammad, M, Thanaraj, T A, Al-Khairi, I, Cherian, P, Channanath, A, Abu-Farha, M, de Vries, N & Abubaker, J 2022, ' The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery ', Sleep and breathing . https://doi.org/10.1007/s11325-022-02736-6
Sleep and breathing
Sleep and breathing. Springer Verlag
ISSN: 1522-1709
1520-9512
DOI: 10.1007/s11325-022-02736-6
Popis: Purpose Obstructive sleep apnea (OSA) is prevalent in the bariatric population. OSA should be recognized in patients undergoing bariatric surgery preoperatively to prevent peri- and post-operative complications. Lipid metabolism-related biomarkers are associated with OSA. Triglyceride metabolism is, among others, regulated by angiopoietin-like protein five (ANGPTL5). We aimed to evaluate the level of ANGPTL5 in patients with OSA of different severity levels before and after bariatric surgery.Methods We performed a single-center prospective cohort study including a consecutive series of patients who underwent bariatric surgery. We collected the clinical data, polysomnography (PSG) or polygraphy (PG) parameters, and plasma derived via venipuncture before and 6 to 12 months after surgery. Lipid profile, glucose levels, and ANGPTL5 levels were assessed. ANGPTL5 levels were measured using an enzyme-linked immunosorbent assay (ELISA).Results The study included 88 patients for analysis. The patients were divided into two subgroups: no or mild OSA (apnea-hypopnea index (AHI) < 15 events/hour, n = 57) and moderate-to-severe OSA (AHI & GE; 15 events/hour, n = 31). The ANGPTL5 level was higher in the moderate-to-severe OSA group (20.5 [15.6, 26.5] ng/mL) compared to the no or mild OSA group (16.3 [12.5, 19.4] ng/mL) (p = 0.008). A significant positive correlation was observed between ANGPTL5 and AHI (rho = 0.256, p = 0.017), apnea index (AI) (rho = 0.318, p = 0.003), and triglyceride levels (rho = 0.240, p = 0.025). ANGPTL5 levels were reduced significantly after bariatric surgery in both moderate-to-severe OSA (15.6 [10.3, 18.7] ng/mL) and no or mild OSA (13.4 [9.2, 15.8] ng/mL) groups, though to a lower level in the group without or mild OSA. Post-surgery, the significant positive correlation between ANGPTL5 and AHI (rho = 0.210, p = 0.047), AI (rho = 0.230, p = 0.034), and triglyceride (rho = 0.397, p < 0.001) remained.Conclusion The data showed increased levels of ANGPTL5 in patients with moderate-to-severe OSA. Both AHI and ANGPTL5 levels decreased significantly after bariatric surgery. We also report an association between ANGPTL5 levels and OSA severity.
Databáze: OpenAIRE
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