Two cases with long-term disease-free survival after resection and radiotherapy for solitary brain metastasis from breast cancer with extensive nodal metastases
| Autor: | Shinsuke Saisho, Kenjiro Aogi, Hideyuki Saeki, Shinji Iwata, Shozo Ohsumi, Shigemitsu Takashima, Koich Mandai, Tetsuji Takeda, Toshiaki Saeki |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Reoperation
medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Disease-Free Survival Neurosurgical Procedures Breast cancer medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Survivors Neoplasm Metastasis Radical mastectomy Neoplasm Staging Radiotherapy Brain Neoplasms business.industry Carcinoma Ductal Breast Brain Cancer General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Radiography Radiation therapy Carcinoma Intraductal Noninfiltrating Treatment Outcome Oncology Lymphatic Metastasis Hormonal therapy Female Neoplasm Recurrence Local Mastectomy Radical business Mastectomy Epirubicin medicine.drug Brain metastasis |
| Zdroj: | Breast Cancer. 12:221-225 |
| ISSN: | 1880-4233 1340-6868 |
| DOI: | 10.2325/jbcs.12.221 |
| Popis: | Two rare cases, each with a solitary brain metastasis from breast cancer with extensive nodal metastases as the first site of distant metastasis, were locally treated with surgery and irradiation. The outcome of the two treated cases indicated an excellent and non-recurrent post-therapeutic survival period of more than 3 and 8 years, respectively. In a 50-year-old woman (Case 1), a solitary brain metastasis was found to have developed after standard radical mastectomy and adjuvant chemotherapy with doxorubicin and tegafur-uracil (UFT) and hormonal therapy with tamoxifen for left breast cancer. The brain metastasis was treated twice surgically followed by radiotherapy. One year and 6 months later, local recurrence of the brain metastasis appeared and was treated surgically again. No other treatment was done thereafter. Since then, no other distant or lymph node metastasis occurred, and to date her outcome has been non-eventful for 8 years and 5 months. In a 63-year-old woman (Case 2), a solitary brain metastasis was found to have developed after standard radical mastectomy and adjuvant chemotherapy with cyclophosphamide, epirubicin and fluorouracil (CEF) for right breast cancer. The brain metastasis was treated locally with surgery and irradiation of 50 Gy. She thereafter received no further treatments. Since then neither distant metastases nor local recurrence have developed, and to date the post-treatment outcome has been uneventful for 37 months. Our findings suggest that patients who developed a solitary brain metastasis as the first site of distant metastasis from breast cancer have a chance of achieving long-term disease-free survival when treated with aggressive local therapy, even in the presence of extensive lymph node metastases at the primary surgery site for breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink