NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers
| Autor: | Matteo Valentino, Caterina Ledda, Lory Santarelli, Antonella Albanesi, Alfredo Copertaro, Veronica Ciarapica, Stefano Esposito, Massimo Bracci, Mariella Barbaresi, Venerando Rapisarda |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Article Subject Circadian clock lcsh:Medicine Physiology Overweight General Biochemistry Genetics and Molecular Biology Shift work 03 medical and health sciences 0302 clinical medicine medicine Circadian rhythm General Immunology and Microbiology business.industry lcsh:R Diurnal temperature variation General Medicine medicine.disease 030210 environmental & occupational health Obesity 030104 developmental biology medicine.symptom Metabolic syndrome Shift Work Schedule business Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2019 (2019) |
| Popis: | Objective. The NOCTURNIN gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of NOCTURNIN in healthy volunteers and its expression levels in rotational shift and daytime workers. Methods. NOCTURNIN expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and NOCTURNIN expression were measured in workers engaged in shift and daytime work. Results. In the group of volunteers NOCTURNIN expression showed diurnal variation, with a peak at 8:00 AM. NOCTURNIN expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting NOCTURNIN expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure. Conclusions. Measuring NOCTURNIN expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher NOCTURNIN levels than daytime workers. |
| Databáze: | OpenAIRE |
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