Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
| Autor: | Valentina Closca, Valeriu Sunel, Cristina-Maria Pavel, Marcel Popa, Corina Popovici, Dan Gheorghe Dimitriu, Dana Ortansa Dorohoi, Diana David, Corina Cheptea |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Magnetic Resonance Spectroscopy
QH301-705.5 Antitubercular Agents Microbial Sensitivity Tests Chemical reaction Article Catalysis Inorganic Chemistry Structure-Activity Relationship Residue (chemistry) Spectroscopy Fourier Transform Infrared Humans Tuberculosis Spectral analysis Biology (General) Physical and Theoretical Chemistry 2-mercapto-benzimidazole QD1-999 Molecular Biology Spectroscopy heterocyclic thiosemicarbazides Chemistry Organic Chemistry Mycobacterium tuberculosis General Medicine Combinatorial chemistry sulfonic derivatives Semicarbazides Computer Science Applications Elemental analysis Proton NMR tuberculostatic activity |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 22 International Journal of Molecular Sciences, Vol 22, Iss 12139, p 12139 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms222212139 |
| Popis: | Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis. |
| Databáze: | OpenAIRE |
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