Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
| Autor: | Connie H. Li, Kim M. Gruver, Daneck Lang-Ouellette, François G. C. Blot, Pauline de Vanssay de Blavous, Phyllis L. Faust, Alanna J. Watt, Carter Van Eitrem, Martijn Schonewille, Chloe A. Stewart, Amy Smith-Dijak, Charlotte Rosen |
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| Přispěvatelé: | Erasmus MC, Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Cerebellum 2019-20 coronavirus outbreak Action potential Science Purkinje cell General Physics and Astronomy Action Potentials Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Mice Purkinje Cells 0302 clinical medicine Intrinsic excitability Cellular neuroscience medicine Animals Learning Action potential generation Axon Multidisciplinary Cerebellar function Brain Neurodegenerative Diseases General Chemistry Enhance (action) Axons Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) Nature Communications Nature Communications, 12(1):4129. Nature Publishing Group |
| ISSN: | 2041-1723 |
| Popis: | Axonal plasticity allows neurons to control their output, which critically determines the flow of information in the brain. Axon diameter can be regulated by activity, yet how morphological changes in an axon impact its function remains poorly understood. Axonal swellings have been found on Purkinje cell axons in the cerebellum both in healthy development and in neurodegenerative diseases, and computational models predicts that axonal swellings impair axonal function. Here we report that in young Purkinje cells, axons with swellings propagated action potentials with higher fidelity than those without, and that axonal swellings form when axonal failures are high. Furthermore, we observed that healthy young adult mice with more axonal swellings learn better on cerebellar-related tasks than mice with fewer swellings. Our findings suggest that axonal swellings underlie a form of axonal plasticity that optimizes the fidelity of action potential propagation in axons, resulting in enhanced learning. Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better. |
| Databáze: | OpenAIRE |
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