Neonatal Intestinal Failure Is Independently Associated With Impaired Cognitive Development Later in Childhood
| Autor: | Laura Merras-Salmio, Taru Häyrinen, Kaisa Kanerva, Riikka Gunnar, Leena Haataja, Mikko P. Pakarinen, Silja Salmi |
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| Přispěvatelé: | Children's Hospital, Helsinki University Hospital Area, Faculty of Medicine, Medicum, Behavioural Sciences, Department of Psychology and Logopedics, HUS Children and Adolescents, University of Helsinki, Lastenkirurgian yksikkö, Clinicum |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics Infant Premature Diseases neonatal surgery NECROTIZING ENTEROCOLITIS 0302 clinical medicine Child Development Cognition Interquartile range Risk Factors 3123 Gynaecology and paediatrics Birth Weight Child Motor skill Intelligence Tests RISK Intelligence quotient Wechsler Preschool and Primary Scale of Intelligence PRETERM Gastroenterology Gestational age 3. Good health Motor Skills Disorders Motor Skills Child Preschool Necrotizing enterocolitis GROWTH 030211 gastroenterology & hepatology Female 3143 Nutrition Infant Premature BIRTH-WEIGHT INFANTS medicine.medical_specialty Adolescent Birth weight Gestational Age parenteral nutrition short bowel syndrome 03 medical and health sciences NEURODEVELOPMENTAL OUTCOMES 030225 pediatrics medicine Humans neurological development Wechsler Intelligence Scale for Children business.industry Infant Newborn SCHOOL-AGE SHORT-BOWEL medicine.disease Cross-Sectional Studies 3121 General medicine internal medicine and other clinical medicine Pediatrics Perinatology and Child Health intelligence quotient business Cognition Disorders CHILDREN BORN |
| Popis: | Objective: The impact of pediatric intestinal failure (IF) on neurodevelopment beyond infancy has not been systematically studied. Our aim was to evaluate cognitive and motor impairment and to identify risk factors for adverse outcomes among children with IF. Methods: We conducted a cross-sectional single-center study at the Helsinki University Children's Hospital. Patients with IF with >60 days of parental nutrition (PN) dependency aged between 3 and 16 years (n = 40) were invited to participate. The cognitive and motor skills were evaluated using validated tests: Wechsler Preschool and Primary Scale of Intelligence, 3rd edition, Wechsler Intelligence Scale for Children, 4th edition, and Movement Assessment Battery for Children, 2nd edition. Results: All the patients attending the study tests (n = 30, males = 24) were included. Their median age, gestational age, and birth weight was 7.5 (range 3-16) years, 35 (interquartile range [IQR] 28-38) weeks and 2238 (IQR 1040-3288) grams, respectively. Median duration of PN was 13 (IQR 5-37) months and 9 patients were currently on PN. Median intelligence quotient was 78 (IQR 65-91) and 10 (35%) patients had an intelligence quotient under 70 (-2 standard deviation). Significant motor impairment was detected in 10 patients (36%) and milder difficulties in 8 (28%). Adverse cognitive outcome was associated with neonatal short bowel syndrome, number of interventions under general anesthesia, and length of inpatient status, whereas adverse motor outcome was associated with prematurity. Conclusion: Clinically significant cognitive and motor impairments are alarmingly common among neonatal patients with IF. We recommend early neurodevelopmental follow-up for all children with IF. |
| Databáze: | OpenAIRE |
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