Brain-derived neurotrophic factor in non-proliferative diabetic retinopathy with diabetic macular edema
| Autor: | Yong Hyun Jun, Seong Taeck Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases genetic structures Diabetic macular edema Aqueous humor Macular Edema Aqueous Humor 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Ophthalmology Diabetes Mellitus medicine Humans Prospective Studies Brain-derived neurotrophic factor Diabetic Retinopathy business.industry Brain-Derived Neurotrophic Factor General Medicine Diabetic retinopathy medicine.disease eye diseases 030221 ophthalmology & optometry business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Ophthalmology. 31:1915-1919 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/1120672120944801 |
| Popis: | Purpose: To investigate aqueous humor (AH) and serum levels of brain-derived neurotrophic factor (BDNF) in non-proliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME). Methods: The prospective study consists of 20 patients with DME NPDR, 20 patients with no-DME NPDR, and 20 healthy control subjects. Serum and AH samples were obtained during cataract surgery and intravitreal injection. Serum and AH levels of BDNF were measured by enzyme-linked immunosorbent assay. Results: The mean serum levels of BDNF were lower in both NPDR groups compared to the control group (DME NPDR group, p = 0.015; no-DME NPDR group, p = 0.024). Furthermore, the mean serum level of BDNF was lower in the DME NPDR group compared to the no-DME NPDR group ( p = 0.041). The mean AH levels of BDNF were significantly reduced in both NPDR groups compared to the control group (DME NPDR group, p Conclusion: Serum and AH levels of BDNF were reduced in NPDR patients with DME than without DME. |
| Databáze: | OpenAIRE |
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