A topical ointment formulation containing leaves’ powder of Lawsonia inermis accelerate excision wound healing in Wistar rats
| Autor: | Hemida Houari, Kalbaza Ahmed Yassine, Amara Karim, Bediaf Imane, Benchohra Mokhtar, Salem Hadjer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Excisional wound
Test group Veterinary medicine wound healing SF1-1100 01 natural sciences 03 medical and health sciences 0302 clinical medicine Collagen fiber SF600-1100 Medicine petroleum jelly General Veterinary Traditional medicine integumentary system business.industry Animal culture 0104 chemical sciences Wistar rats 010404 medicinal & biomolecular chemistry Lawsonia inermis 030220 oncology & carcinogenesis excision Wound healing agent business Topical ointment Wound healing Excision wound Research Article |
| Zdroj: | Veterinary World Veterinary World, Vol 13, Iss 7, Pp 1280-1287 (2020) |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Aim: Lawsonia inermis (LI), a naturally grown or cultivated shrub in Northeast of Africa and India, has been traditionally used as a strong remedy for several injuries. However, few studies have reported its use as a cicatrizing agent. The aim of this study was to evaluate the effect of daily application of an ointment prepared with LI leaves' powder on wound healing in Wistar rats. Materials and Methods: Twenty female Wistar rats were used in this study. Excisional wound model was realized by removing skin from the dorsal part of the neck of each animal. Wounds have been then treated by a daily application of LI ointment prepared by mixing leaves' powder to petroleum jelly in test group and by simple application of petroleum jelly in control group. Evaluation of wound healing activity was then based on calculating the percentage of wound contraction, period of epithelialization, and wound index every 3 days for a period of 24 days, then, a histological study of the healed excised wound was performed. Results: Treatment with LI has shown excellent wound healing activity, since it has increased percent of wound contraction, and reduced period of epithelialization and wound index as compared to control (p |
| Databáze: | OpenAIRE |
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