Urinary neutrophil gelatinase-associated lipocalin in critically ill surgical cancer patients
| Autor: | Vanessa Wandeur, Péricles Almeida Delfino Duarte, Delmiro Becker, Andreia C. Fumagalli |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
APACHE II business.industry Urinary system Incidence (epidemiology) Acute kidney injury neoplasms Cancer Critical Care and Intensive Care Medicine medicine.disease urologic and male genital diseases Intensive care unit female genital diseases and pregnancy complications Surgery law.invention law inflammation Internal medicine Etiology Medicine postoperative business Prospective cohort study Research Article |
| Zdroj: | Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine |
| ISSN: | 0972-5229 |
| Popis: | Background and Aims: Neutrophil gelatinase-associated lipocalin (N-GAL) is an early biomarker of acute kidney injury (AKI) due to various etiologies. On the other hand, N-GAL is also elevated in patients with acute inflammatory conditions and in several solid neoplasms. The goal of this study was to assess the efficacy of N-GAL as a predictor of AKI and mortality in oncological surgical patients postoperatively in the intensive care unit (ICU). Methods: This was a prospective cohort observation study on adult cancer patients submitted to elective or emergency surgeries and admitted in the ICU. Urinary N-GAL was measured at the first 2 h after admission. AKI incidence and other complications were assessed, including hospital mortality. Results: A total of 22 patients were assessed (77% male, age 52.8 years, Acute Physiology and Chronic Health Evaluation II [APACHE II] 17.3) in whom the most frequent site of cancer was the gastrointestinal tract. AKI incidence was 13.6%. Urinary N-GAL was a predictor of AKI (22.0 ng/ml in patients without AKI vs. 239.1 ng/ml in patients with AKI, P < 0.001). Multivariate analysis showed that the main predictors of AKI were age, APACHE II, and N-GAL. N-GAL was also higher, although not statistically significant in patients who died in the hospital. Conclusions: In oncological postoperative patients admitted to the ICU, urinary N-GAL was an independent predictor of AKI; moreover, its level was higher in the deceased patients. |
| Databáze: | OpenAIRE |
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