Cobalt protoporphyrin decreases food intake, body weight, and the number of neurons in the Nucleus Accumbens in female rats
| Autor: | José Pedraza-Chaverri, Luis Fernando Rubio-Atonal, Norma Serrano-García, Marisol Orozco-Ibarra, Jorge H. Limón-Pacheco |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Food intake Protoporphyrins Anorexia Nucleus accumbens Body weight Nucleus Accumbens Eating 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Hypophagia medicine Animals Rats Wistar Molecular Biology Neurons Chemistry General Neuroscience Body Weight COPP Cobalt protoporphyrin Rats 030104 developmental biology Endocrinology Female Neurology (clinical) medicine.symptom 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1758:147337 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2021.147337 |
| Popis: | Cobalt protoporphyrin (CoPP) is a potent heme oxygenase-1 inductor that produces temporary hypophagia and chronic weight loss. A complete description of this effect and the underlying mechanisms are unknown. In this work, we challenged the ability of CoPP to produce changes in rat behavior and cellular alterations in the Nucleus Accumbens that would explain those effects. We subcutaneously administered 25 µmol/kgbody weight CoPP in female rats and determined body weight, food intake, hyperactivity, and anxiety-like behavior, as well as the number of neurons and glial cells in the Nucleus Accumbens. CoPP significantly reduced food intake, water consumption, and body weight. Behavioral tests showed that anxiety-like behaviors and locomotor activity were not modified five days after the administration of CoPP. We also found a reduced number of neurons in the Nucleus Accumbens Shell. The above results could be relevant to diseases like anorexia, so it is necessary to deepen the study about the molecular mechanisms involved in reducing the food intake and weight loss elicited by CoPP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect