Gold‐Speckled SPION@SiO 2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications

Autor:	Angela Agostiano, Roberto Comparelli, Fabio Canepa, Michela Corricelli, Daniela Comegna, Nunzio Denora, Annarita Del Gatto, Marinella Striccoli, Valentino Laquintana, Giulia Siciliano, Sapia Murgolo, Rosa Maria Iacobazzi, Giuseppe Mascolo, Michele Saviano, Laura Zaccaro, M. Lucia Curri, Nicoletta Depalo, Elisabetta Fanizza
Rok vydání:	2020
Předmět:	ASGPR1 receptor bioconjugates gold/silica nanoparticles SPIONs thiocarbohydrate ligands medicine.diagnostic_test Superparamagnetic iron oxide nanoparticles 010405 organic chemistry Chemistry Organic Chemistry Dual mode Nanoparticle Nanotechnology Magnetic resonance imaging General Chemistry Conjugated system 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Sio2 nanoparticles medicine Asialoglycoprotein receptor Superparamagnetism
Zdroj:	Chemistry (Weinh., Print) (2020). doi:10.1002/chem.202002142 info:cnr-pdr/source/autori:Siciliano, Giulia; Corricelli, Michela; Iacobazzi, Rosa Maria; Canepa, Fabio; Comegna, Daniela; Fanizza, Elisabetta; Del Gatto, Annarita; Saviano, Michele; Laquintana, Valentino; Comparelli, Roberto; Mascolo, Giuseppe; Murgolo, Sapia; Striccoli, Marinella; Agostiano, Angela; Denora, Nunzio; Zaccaro, Laura; Curri, M. Lucia; Depalo, Nicoletta/titolo:Gold-Speckled SPION@SiO2<%2Finf> Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications/doi:10.1002%2Fchem.202002142/rivista:Chemistry (Weinh., Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202002142
Popis:	Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non-invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well-established contrasting features in magnetic resonance imaging (MRI) and X-ray computed tomography (CT), respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 (ASGPR1) overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au-speckled silica-coated SPIONs NPs, to achieve two original nanostructures that could be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, well-controlled size and morphology and good selectivity for targeting ASGPR1 receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aade9a8e89cbfea17f027698dc21587 https://doi.org/10.1002/chem.202002142 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.