Signs of neutrophil and eosinophil activation in adult respiratory distress syndrome
| Autor: | Jan Modig, Per Venge, Tommy Borg, Roger Hällgren |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male ARDS Granulocyte activation Adolescent Critical Care Neutrophils Critical Care and Intensive Care Medicine Ribonucleases fluids and secretions Eosinophil activation medicine Humans Eosinopenia Prospective Studies Complement Activation Aged Respiratory Distress Syndrome Eosinophil cationic protein biology Respiratory distress Lactoferrin business.industry Blood Proteins Eosinophil Granule Proteins Middle Aged medicine.disease Shock Septic Specific granule Immunology biology.protein Wounds and Injuries Female business |
| Zdroj: | Critical Care Medicine. 12:14-18 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/00003246-198401000-00004 |
| Popis: | Circulating levels of lactoferrin, a specific granule protein of neutrophilic leukocytes, and eosinophil cationic protein (ECP), a specific granule protein of eosinophilic leukocytes, were serially measured in 19 patients at risk for adult respiratory distress syndrome (ARDS). Those patients who developed ARDS had significantly higher concentrations of both proteins than the patients without signs of ARDS. High ECP levels were observed in spite of peripheral eosinopenia. The lactoferrin levels were also increased in relation to circulating numbers of neutrophils. These findings are consistent with an enhanced turnover and/or activity of eosinophils and neutrophils in ARDS and thereby support other clinical and experimental observations suggesting a central pathophysiologic role for granulocytes in ARDS. No relation was found between ARDS or serum concentrations of lactoferrin or ECP and degree of complement consumption, suggesting that other mechanisms besides complement activation may underlie granulocyte activation in ARDS. |
| Databáze: | OpenAIRE |
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