Immunomodulatory properties of oat and barley β-glucan populations on bone marrow derived dendritic cells
| Autor: | Roy J.B.M. Delahaije, Jerry M. Wells, Harry Gruppen, Christiane Rösch, Henk A. Schols, Nico Taverne, Marjolein Meijerink |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) 02 engineering and technology macromolecular substances Dendritic cells Immunomodulation 03 medical and health sciences Equivalent Levensmiddelenchemie medicine Homogenisation TX341-641 Host-Microbe Interactomics Glucan VLAG chemistry.chemical_classification Particulate Nutrition and Dietetics Food Chemistry Nutrition. Foods and food supply Granule (cell biology) food and beverages 021001 nanoscience & nanotechnology In vitro carbohydrates (lipids) TLR2 stomatognathic diseases 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry Solubility Knockout mouse WIAS Tumor necrosis factor alpha Bone marrow 0210 nano-technology Food Science |
| Zdroj: | Journal of Functional Foods 26 (2016) Journal of Functional Foods, 26, 279-289 Journal of Functional Foods, Vol 26, Iss, Pp 279-289 (2016) |
| ISSN: | 1756-4646 |
| Popis: | Specific structures of oat and barley β(1,3)(1,4)-glucans induced different in vitro immunomodulatory effects in bone marrow derived dendritic cells (BMDC) from TLR2/4 knock out mice. All barley β-glucan fractions induced larger amounts of cytokines in BMDCs than their oat equivalents. The particulate fractions of both glucans induced high amounts of cytokines, especially after sample homogenisation. The small particulate barley β-glucans induced more cytokines than the equivalent oat fraction, hence there are more features influencing the immunomodulatory properties of β-glucans than only the particle size. The soluble glucan fraction and heated suspension induced only low amounts of cytokines, but were different for the two β-glucans, indicating that molecular specificity matters for immunomodulation. Immunomodulatory activity is influenced by the insolubility of β-glucans, to which characteristics as particle size, granule conformation and particulate homogeneity are related. Consequently, sample preparation influences the immunomodulatory activity of β-glucans. |
| Databáze: | OpenAIRE |
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