Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats
| Autor: | Kumiko Yoshimatsu, Ikuo Takashima, M. Kimura, Nobuo Hashimoto, Hiroaki Kariwa, S. Yoshizumi, Jiro Arikawa |
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| Rok vydání: | 1996 |
| Předmět: |
Orthohantavirus
Time Factors Genes Viral Hantavirus Infections Antibody Affinity Genome Viral Biology Antibodies Viral Kidney Polymerase Chain Reaction Sensitivity and Specificity Virus Viral Proteins Neutralization Tests Virology Chlorocebus aethiops Animals Rats Wistar Neutralizing antibody Lung Vero Cells Cells Cultured Disease Reservoirs Hantavirus General Medicine biology.organism_classification Rats Reverse transcription polymerase chain reaction Titer Immunoglobulin G biology.protein RNA Viral Antibody Bunyaviridae Seoul virus |
| Zdroj: | Archives of Virology. 141:2327-2338 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/bf01718634 |
| Popis: | To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months. |
| Databáze: | OpenAIRE |
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