Morphine Suppresses Liver Cancer Cell Tumor Properties In Vitro and In Vivo
| Autor: | Ya-Qun Zhou, Zhan-Guo Zhang, Shi-Ying Yu, San-Ping Xu, Fei Wang, Hao-Wen Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Analgesic Pharmacology Metastasis liver cancer Nude mouse In vivo medicine metastasis RC254-282 Original Research biology business.industry Cancer opioids Neoplasms. Tumors. Oncology. Including cancer and carcinogens morphine medicine.disease biology.organism_classification digestive system diseases Oncology Apoptosis Morphine tumorigenicity Liver cancer business medicine.drug |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| DOI: | 10.3389/fonc.2021.666446/full |
| Popis: | Morphine is an analgesic widely adopted to relieve cancer pain. A number of discrepancies, however, are presented by the published literature, with reports suggesting that opioids may either promote or inhibit the spread of cancer. It is of great significance to determine whether morphine may increase the risk of metastasis while utilized in liver cancer surgical treatment. In this study, we explore the effects of morphine on liver cancer cells in vitro and in vivo. Our results showed that morphine does not promote proliferative ability to cultured liver cancer cells. While morphine could increase the apoptosis rate of Hep3B/HepG2 cells. Furthermore, morphine could significantly inhibit the migratory and invasion ability of Hep3B/HepG2 cells. Subsequent investigations disclosed that morphine could inhibit sphere formation ability of Hep3B/HepG2 cells by using sphere formation assay. Based on nude mouse models, we demonstrated that morphine significantly reduced pulmonary tumorigenicity of Hep3B/HepG2 cells. In conclusion, our results found that morphine at clinical concentrations could suppress liver cancer cell tumor properties in vitro and in vivo, indicating the safety of morphine utilization in HCC patients’ pain management. |
| Databáze: | OpenAIRE |
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