| Autor: |
Dong-Ming Kuang, Limin Zheng, Chuan-Lu Liu, Xue-Feng Li, Qiyi Zhao, Xiao-Yu Zhao, Dong-Ping Chen, Fang-Zhu Ouyang, Yuan Wei, Rui-Xian Liu, Min-Min Chen, Xiang-Ming Lao, Xiao Xiao |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22530924 |
| Popis: |
Supplementary Figure S1 shows association of PD-1+ and PD-1high B cells in tumor tissue with disease recurrence, plasma HBV DNA and cytokines in HCC patients, and surface markers on HCC B cells. Supplementary Figure S2 shows gating strategies for FACS, and the phenotypic and functional features of the B cell subsets. Supplementary Figure S3 expands data on factors that modulate PD-1 expression on B cells in HCC. Supplementary Figure S4 expands data on roles of Bcl-6 and STAT6 in B cell PD-1 regulation. Supplementary Figure S5 expands data on effects of PD-1 agonist on B cells. Supplementary Figure S6 expands data on effects of PD-1 triggering by PD-L1-expressing cells. Supplementary Figure S7 expands data on triggering PD-1 in B cells suppresses tumor-specific immunity. Supplementary Figure S8 shows graphical abstract for the results. Supplementary Figure S9 shows Isotype staining of FACS and immunohistochemistry (IHC) using clinical samples. Supplementary Figure S10 shows the negative expression of monocyte subset markers in tumor B cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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