Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain–Barré syndrome in Bangladesh
| Autor: | Israt Jahan, Mohammad I. Rahman, Shamsun Nahar, Rijwan Uddin Ahammad, Quazi D. Mohmmad, Zhahirul Islam, Kaniz Sharmin Farzana, Yearul Kabir, Mohammad B. Islam, Mir M. Khalid |
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| Přispěvatelé: | Medical Microbiology & Infectious Diseases |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Immunology Single-nucleotide polymorphism Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Genotype medicine Immunology and Allergy biology Guillain-Barre syndrome business.industry bacterial infections and mycoses medicine.disease 030104 developmental biology Neurology biology.protein bacteria Tumor necrosis factor alpha Neurology (clinical) Antibody business Polyneuropathy 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology, 310, 46-50. Elsevier |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2017.06.005 |
| Popis: | Guillain-Barre syndrome (GBS) is a post-infectious autoimmune polyneuropathy regulated by pro- and anti-inflammatory cytokines; TNFA polymorphisms may exert immune pathogenic roles in GBS. We assessed TNFA promoter region polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A) in Bangladeshi patients with GBS (n = 300) and healthy controls (n = 300) by PCR-RFLP and ASO-PCR. TNFA -863CA was significantly associated with GBS disease susceptibility (P = 0.0154) and disease severity (P = 0.0492). TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P = 0.0092) and -863AA associated with AMAN subtype of GBS (P = 0.0398). TNFA -863C/A may contribute to GBS severity and pathogenesis in Bangladeshi patients. |
| Databáze: | OpenAIRE |
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