Prevalence and clinical predictors of LPR among patients diagnosed with GERD according to the reflux symptom index questionnaire

Autor: Osama A. Marglani, Hani Jawa, Mazin Merdad, Hani Z Marzouki, Talal Al-Khatib, Mahmoud Mosli, Bashaer Alkhathlan, Abdulmalik Ghassan Abumohssin, Ameen Z. Alherabi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Cross-sectional study
gastroesophageal reflux disease
Statistics as Topic
Saudi Arabia
severity
Comorbidity
Logistic regression
Severity of Illness Index
03 medical and health sciences
Laryngopharyngeal reflux
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Surveys and Questionnaires
Severity of illness
Prevalence
Medicine
Humans
lcsh:RC799-869
030223 otorhinolaryngology
Life Style
business.industry
laryngopharyngeal reflux
Gastroenterology
Middle Aged
medicine.disease
digestive system diseases
Correlation
Cross-Sectional Studies
Predictive value of tests
GERD
Gastroesophageal Reflux
030211 gastroenterology & hepatology
Female
Original Article
lcsh:Diseases of the digestive system. Gastroenterology
business
Body mass index
Zdroj: The Saudi Journal of Gastroenterology, Vol 24, Iss 4, Pp 236-241 (2018)
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
ISSN: 1998-4049
1319-3767
Popis: Background/Aims: Gastroesophageal reflux disease (GERD) is a common condition that can lead to significant morbidity. Laryngopharyngeal reflux (LPR) is a distinct clinical entity that can occur simultaneously with GERD, necessitating additional treatment measures. The degree of overlap and clinical predictors of LPR among patients with GERD remains unknown. We aim to measure the prevalence of LPR in patients with GERD and identify clinical predictors. Patients and Methods: We performed a cross-sectional study involving patients with confirmed GERD according to the GERD questionnaire (GerdQ) using the reflux symptom index (RSI). Data on demographics, comorbidities, past and current medications, and GERD-related lifestyle measures were documented. The prevalence of LPR was calculated. Linear and logistic regression analyses were conducted to correlate GerdQ and RSI, and to identify clinical predictors of LPR, respectively. Results: A total of 80 patients with confirmed GERD were consecutively recruited and surveyed. Mean age was 43 (±16) and 60% were females. The majority of patients were Saudis (51%) and only 24% were smokers. The mean duration of GERD was 7 (±4.4) years and the average body mass index (BMI) was 36 ± 22. Sixty-six percent of the patients consumed coffee on regular basis. On simple and multiple linear regression analyses, a strong, positive correlation was observed between the GerdQ and RSI scores (coefficient = 1.13, 95%CI = 0.39–1.86), and ipratropium bromide inhaler was positively associated with RSI scores (coefficient = 13.12, 95%CI = 0.16–26.09). LPR was identified in 57 patients (71%). On simple and multiple logistic regression analyses, GerdQ scores (OR = 1.78, 95%CI = 1.13–2.80), BMI (OR = 1.07, 95%CI = 1.01–1.14), duration of GERD in years (OR = 1.42, 95%CI = 1.04–1.93), and the type of gender (OR = 49.67, 95%CI = 1.32–1870) appeared to increase the risk of LPR, whereas coffee consumption (OR = 0.0005, 95%CI = 1.82e–06, 0.13) appeared to be negatively associated with LPR. Conclusions: Contradictory to what is frequently reported, LPR commonly occurs and positively correlates with GERD. Several modifiable clinical predictors of LPR might exist, which highlight the importance of performing a complete clinical assessment of the patients with reflux symptoms.
Databáze: OpenAIRE
Externí odkaz: