A comparison of insulin lispro Mix25™ and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan
| Autor: | L.K. Levitt, M. Schwarzenhofer, H. Tounsi, Zvonko Milicevic, Vinod Mattoo, N. Rais, L.H.C. Liong, James Malone, A. Ekangaki |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Evening Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Islam Endocrinology Internal medicine Diabetes mellitus Internal Medicine Humans Hypoglycemic Agents Insulin Medicine Insulin lispro Morning Cross-Over Studies Insulin Lispro business.industry Blood Glucose Self-Monitoring digestive oral and skin physiology Fasting General Medicine Middle Aged Postprandial Period medicine.disease Crossover study Postprandial Diabetes Mellitus Type 2 Female business medicine.drug |
| Zdroj: | Diabetes Research and Clinical Practice. 59:137-143 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/s0168-8227(02)00202-4 |
| Popis: | Objective: To compare insulin lispro Mix25 and human insulin 30/70 with regard to their effect on morning and evening postprandial glucose (PPG) control, and on average daily blood-glucose (BG), in patients with Type 2 diabetes who wish to fast during Ramadan. Method: Insulin lispro Mix25 and human insulin 30/70 were compared in an open-label, multicenter, randomised, crossover study involving 151 patients. Each treatment period had a duration of 14 days during which the patients self-monitored their BG before and 2 h after the main meals on any 3 days within the last 5 days of each treatment period. Results: The 2 h PPG excursion following the main evening meal after sunset was significantly lower with insulin lispro Mix25 (3.4±2.9 mmol/l) compared with human insulin 30/70 (4.0±3.2 mmol/l, P =0.007). The evening pre-meal fasting BG values were also lower with insulin lispro Mix25 (7.1±2.2 mmol/l) versus human insulin 30/70 (7.5±2.6 mmol/l, P =0.034). The average daily BG concentration was 9.5±2.4 mmol/l during treatment with insulin lispro Mix25 versus 10.1±2.5 mmol/l with human insulin 30/70 given in identical doses ( P =0.004). Conclusion: When compared with human insulin 30/70, treatment of insulin-requiring Type 2 patients with insulin lispro Mix25 during Ramadan resulted in better average daily glycaemia, and better BG control before and after the evening meal. Insulin lispro Mix25 should be considered as a therapeutic option during Ramadan. |
| Databáze: | OpenAIRE |
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