Cervical re-injection of indocyanine green to improve sentinel lymph node detection in endometrial cancer
| Autor: | Maria Teresa Achilarre, Matteo Maruccio, C. Quatrale, Angelo Maggioni, Ilaria Betella, Annalisa Garbi, Giovanni Aletti, Stefano Bogliolo, Andrea Mariani, Vanna Zanagnolo, Nicoletta Colombo, M. Maramai, Francesco Multinu, Alessia Aloisi |
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| Přispěvatelé: | Maramai, M, Achilarre, M, Aloisi, A, Betella, I, Bogliolo, S, Garbi, A, Maruccio, M, Quatrale, C, Aletti, G, Mariani, A, Colombo, N, Maggioni, A, Multinu, F, Zanagnolo, V |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Sentinel lymph node algorithm medicine.medical_treatment Sentinel lymph node Salpingo-oophorectomy Surgical staging Hysterectomy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Robotic Surgical Procedures Endometrial cancer Biopsy medicine Humans In patient Stage (cooking) Neoplasm Staging Retrospective Studies Re-injection Chemotherapy medicine.diagnostic_test business.industry Obstetrics and Gynecology Middle Aged medicine.disease Indocyanine green Endometrial Neoplasms 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Lymph Node Excision Female Lymph Nodes Radiology Sentinel Lymph Node business |
| Zdroj: | Gynecologic Oncology. 162:38-42 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/j.ygyno.2021.04.026 |
| Popis: | Objectives To evaluate the role of cervical re-injection of indocyanine green (ICG) to increase the detection rate of sentinel lymph node (SLN) in patients with endometrial cancer (EC) who underwent robotic-assisted surgical staging. Methods We retrospectively identified consecutive EC patients undergoing robotic-assisted staging with SLN biopsy at our Institution between June 2016 and April 2020. Patients were excluded if they had open abdominal surgical approach, neoadjuvant chemotherapy, and advanced stage [International Federation of Gynecology and Obstetrics (FIGO) stage III-IV] at diagnosis. According to our SLN protocol, in case of either unilateral or no SLN detection, we performed an ipsilateral or bilateral cervical re-injection of ICG. Results In total, 251 patients meeting inclusion criteria were included in the analysis. At first injection, bilateral detection was achieved in 184 (73.3%), unilateral detection in 57 (22.7%), and no detection in 10 (4.0%) patients. Cervical re-injection was performed in 51 of 67 patients with failed bilateral mapping. After cervical re-injection, bilateral detection rate increased to 94.5% (222/235), while unilateral and no detection were 5.1% (12/235) and 0.4% (1/235), respectively. Conclusions Our results suggest that cervical re-injection of ICG, in case of failed bilateral mapping of SLN, brings about a significant improvement in SLN detection rates, therefore reducing the number of side-specific required lymphadenectomies. |
| Databáze: | OpenAIRE |
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