Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review
| Autor: | Sileny Han, Frédéric Amant, Kristel Van Calsteren, Mina Mhallem Gziri, Anouk Lotgerink, Myriam Hanssens |
|---|---|
| Přispěvatelé: | UCL - (SLuc) Service d'obstétrique |
| Jazyk: | angličtina |
| Předmět: |
Anti-Mullerian Hormone
medicine.medical_specialty human epididymis secretory protein 4 (HE4) Genital Neoplasms Female lcsh:Medicine CA 15-3 Physiology Breast Neoplasms inhibin B chemistry.chemical_compound Breast cancer CA 125 Antigens Neoplasm Pregnancy Internal medicine Lactate dehydrogenase medicine Biomarkers Tumor cancer Humans Inhibins Cervical cancer Medicine(all) biology L-Lactate Dehydrogenase business.industry lcsh:R Cancer Anti-Müllerian hormone lactate dehydrogenase General Medicine medicine.disease Endocrinology anti-Müllerian hormone squamous-cell carcinoma antigen tumor markers chemistry Tumor Markers Biological biology.protein Female business Ovarian cancer Pregnancy Complications Neoplastic Research Article |
| Zdroj: | BMC Medicine BMC Medicine, Vol. 10, no.1, p. 86 (2012) BMC Medicine, Vol 10, Iss 1, p 86 (2012) |
| ISSN: | 1741-7015 |
| DOI: | 10.1186/1741-7015-10-86 |
| Popis: | Background Recent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations during pregnancy, the most common tumor markers used in diagnosis and follow-up of gynecological cancers. Methods We conducted a systematic review of six tumor markers during normal pregnancy: carbohydrate antigen (CA) 15-3 (breast cancer); squamous cell carcinoma antigen (cervical cancer); and CA 125, anti-Müllerian hormone, inhibin B and lactate dehydrogenase (ovarian cancer). Results For CA 15-3, 3.3% to 20.0% of all measurements were above the cut-off (maximum 56 U/mL in the third trimester). Squamous cell carcinoma antigen values were above cut-off in 3.1% and 10.5% of the measurements (maximum 4.3 µg/L in the third trimester). Up to 35% of CA 125 levels were above cut-off: levels were highest in the first trimester, with a maximum value up to 550 U/mL. Inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels were not elevated in maternal serum during normal pregnancy. Conclusion During normal pregnancy, tumor markers including CA 15.3, squamous cell carcinoma antigen and CA 125 can be elevated; inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels remain below normal cut-off values. Knowledge of physiological variations during pregnancy can be clinically important when managing gynecological cancers in pregnant patients. |
| Databáze: | OpenAIRE |
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