A facile and efficient method for the synthesis of N-substituted-3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid
| Autor: | Min Lei, Lihong Hu, Zha-Jun Zhan, Ling-Jun Hu |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | ARKIVOC, Vol 2013, Iss 3, Pp 189-198 (2013) |
| ISSN: | 1551-7012 |
| Popis: | A new and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives by a one-pot, three-component condensation reaction of 2-carboxybenzaldehyde, primary amine, and TMSCN in the presence of 10 mol % sulfamic acid (NH2SO3H) as the catalyst in EtOH under reflux temperature is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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