Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons
| Autor: | Maia A Burjanadze, Revaz Solomonia, Manana Kandashvili, Manana G Dashniani, Temur L. Naneishvili, Mariam R. Chighladze, Nino C Chkhikvishvili, Gela V Beselia, Lali B. Kruashvili |
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| Rok vydání: | 2020 |
| Předmět: |
General Neuroscience
05 social sciences Glutamate receptor Cholinergic Agents Hippocampus Morris water navigation task AMPA receptor Hippocampal formation Biology 050105 experimental psychology Rats Receptors Neurotransmitter 03 medical and health sciences Glutamatergic 0302 clinical medicine Cholinergic GABAergic Animals 0501 psychology and cognitive sciences GABAergic Neurons Maze Learning Neuroscience 030217 neurology & neurosurgery Spatial Memory |
| Zdroj: | Experimental brain research. 238(10) |
| ISSN: | 1432-1106 |
| Popis: | The medial septum (MS) is an important modulator of hippocampal function. The degree of damage in which the particular set of septo-hippocampal projections contributes to the deficits of spatial memory with concomitant changes of hippocampal receptors expression has not been studied till present. Therefore, we investigated spatial memory and the expression level of cholinergic (α7 nACh and M1), GABAergic (α1 subunit of GABAA) and glutamatergic (NR2B subunit of NMDA and GluR 1 subunit of AMPA) receptors in the hippocampus following selective lesions of cholinergic and GABAergic septo-hippocampal projection. Learning process and long-term spatial memory were assessed using a Morris water maze. The obtained results revealed that in contrast to cholinergic lesions, rats with MS GABAergic lesions exhibit a retention deficit in 3 days after training. Western blot analyses revealed the MS cholinergic lesions have significant effect on the expression level of the M1 mACh receptors, while MS GABAergic lesions induce dramatic modulations of hippocampal glutamatergic, cholinergic and GABAergic receptors expression. These results for the first time demonstrated that selective lesions of MS cholinergic and GABAergic neurons differentially affect long-term spatial memory and the memory deficit after MS GABAergic lesion is paralleled with significant changes of hippocampal glutamate, GABA and acetylcholine receptors expression. |
| Databáze: | OpenAIRE |
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