Periodic limb movement in sleep and sickle cell disease: a neglected association?
| Autor: | Sergio Tufik, Suely Roizenblatt, Maria Stella Figueiredo, Altay Alves Lino de Souza, Ana Carolina Cabañas-Pedro |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Erythrocyte Indices Male medicine.medical_specialty Movement 030232 urology & nephrology Anemia Sickle Cell Disease Polysomnography Logistic regression Young Adult 03 medical and health sciences 0302 clinical medicine Disease severity Reticulocyte count hemic and lymphatic diseases Internal medicine Odds Ratio medicine Humans medicine.diagnostic_test business.industry Extremities Hematology Sleep in non-human animals Unconjugated bilirubin Physical therapy Female Iron status Sleep business 030217 neurology & neurosurgery |
| Zdroj: | British Journal of Haematology. 179:154-157 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/bjh.14811 |
| Popis: | Summary High frequency of periodic limb movements in sleep (PLMS) has been described among children with sickle cell disease (SCD), but there is little information about PLMS among adults with SCD. We aim to determine the frequency of PLMS among adults with SCD and to identify possible associations with iron status and haemolytic parameters. We analysed polysomnography on 99 adults: 74 with sickle cell anaemia (HbSS), 19 with HbSC (double heterozygosis HbS and HbC) and 6 with HbS-beta thalassaemia. Laboratory data were collected close to the time of the polysomnography examination. The prevalence of PLMS > 5/h was 70% and of PLMS > 15/h 36%, in the total group of patients. No differences were observed regarding gender, use of hydroxyurea and iron parameters. Logistic regression showed an association between PLMS > 15/h and hemolytic parameters: absolute reticulocyte count (p = 0.03) and unconjugated bilirubin (p = 0.01). Our data suggest that PLMS may be associated with manifestations of greater severity in SCD. |
| Databáze: | OpenAIRE |
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