Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy
| Autor: | Sini Korpelainen, Sari Hämäläinen, Kari Pulkki, Irma Koivula, Esa Jantunen, Matti Vänskä, Anna-Kaisa Purhonen, Auni Juutilainen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Immunology Biochemistry Gastroenterology Leukocyte Count Plasma Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy Blood culture Molecular Biology Multiple myeloma Aged Febrile Neutropenia medicine.diagnostic_test Septic shock business.industry Lymphoma Non-Hodgkin Interleukin-18 Hematology Middle Aged medicine.disease Shock Septic Lymphoma 030104 developmental biology Hematologic Neoplasms 030220 oncology & carcinogenesis Biomarker (medicine) Female Interleukin 18 Stem cell business Febrile neutropenia |
| Zdroj: | Cytokine. 129:155021 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2020.155021 |
| Popis: | In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma. |
| Databáze: | OpenAIRE |
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