A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
| Autor: | Tomas Trnovec, Tomas Nemessanyi, Beata Drobná, Anna Fabišiková, Terrance J. Kavanagh, Todd A. Jusko, Eva Jahnova, Irva Hertz-Picciotto, B. Paige Lawrence, Lubica Palkovicova, Stephen M. Schwartz, Anneclaire J. De Roos, Dean Sonneborn, Anton Kočan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Diphtheria Toxoid Offspring Physiology Biology Biochemistry Article Cohort Studies Young Adult chemistry.chemical_compound Immune system Pregnancy Immunopathology Tetanus Toxoid medicine Humans Young adult Haemophilus Vaccines General Environmental Science organic chemicals Haemophilus influenzae type b Infant Polychlorinated biphenyl Environmental Exposure Fetal Blood medicine.disease Antibodies Bacterial Polychlorinated Biphenyls Vaccination chemistry Maternal Exposure Immunoglobulin G Bacterial Vaccines Immunology bacteria Female Growth and Development Cohort study |
| Zdroj: | Environmental Research. 110:388-395 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2010.02.010 |
| Popis: | Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study.The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age.Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener.At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect