Surgical Practice in Girls with Congenital Adrenal Hyperplasia: An International Registry Study
| Autor: | Ana Vieites, Liat de Vries, Christa E. Flück, Jennyver-Tabea Schröder, Christoph Krall, Daniel Konrad, Eduardo Corrêa Costa, Jillian Bryce, Niels H Birkebaek, Ruth Krone, Hedi Claahsen van der Grinten, Sabah Alvi, Carlo L. Acerini, Tulay Guran, Violeta Iotova, Rieko Tadokoro Cuccaro, Rita Ortolano, Ieuan A. Hughes, Mario Lima, Doris Hebenstreit, Evelien F. Gevers, Birgit Koehler, Sukran Poyrazoglu, Ayla Güven, Fuat Bugrul, Tatjana Milenkovic, Nils Krone, Alexander Springer, S Faisal Ahmed, Richard J. Ross, Walter Bonfig |
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| Přispěvatelé: | Hebenstreit D., Ahmed F.S., Krone N., Krall C., Bryce J., Alvi S., Ortolano R., Lima M., Birkebaek N., Bonfig W., Claahsen Van Der Grinten H., Costa E.C., Poyrazoglu S., De Vries L., Fluck C.E., Guran T., Bugrul F., Guven A., Iotova V., Koehler B., Schroder J.-T., Konrad D., Gevers E., Krone R., Milenkovic T., Vieites A., Ross R., Tadokoro Cuccaro R., Hughes I., Acerini C., Springer A., Hebenstreit, Doris, Ahmed, Faisal S., Krone, Nils, Krall, Christoph, Bryce, Jillian, Alvi, Sabah, Ortolano, Rita, Lima, Mario, Birkebaek, Niels, Bonfig, Walter, Claahsen van der Grinten, Hedi, Costa, Eduardo Correa, Poyrazoglu, Sukran, de Vries, Liat, Fluck, Christa E., Guran, Tulay, Bugrul, Fuat, Guven, Ayla, Iotova, Violeta, Koehler, Birgit, Schroeder, Jennyver-Tabea, Konrad, Daniel, Gevers, Evelien, Krone, Ruth, Milenkovic, Tatjana, Vieites, Ana, Ross, Richard, Tadokoro Cuccaro, Rieko, Hughes, Ieuan, Acerini, Carlo, Springer, Alexander, University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Embryology
medicine.medical_specialty Disorders of sexual development DISORDERS Endocrinology Diabetes and Metabolism Registry study 610 Medicine & health 21-HYDROXYLASE DEFICIENCY Biology Logistic regression 1309 Developmental Biology Early surgery Endocrinology medicine Humans Congenital adrenal hyperplasia Registries Adrenal Hyperplasia Congenital General surgery 2710 Embryology medicine.disease Urogenital Surgical Procedures ddc Diabetes and Metabolism 2712 Endocrinology Diabetes and Metabolism 10036 Medical Clinic Current practice ENDOCRINE-SOCIETY Genital surgery Intersex Female Surgery Genitoplasty Vaginal surgery Developmental Biology |
| Zdroj: | Hebenstreit, Doris; Ahmed, S Faisal; Krone, Nils; Krall, Christoph; Bryce, Jillian; Alvi, Sabah; Ortolano, Rita; Lima, Mario; Birkebaek, Niels; Bonfig, Walter; Claahsen van der Grinten, Hedi; Costa, Eduardo Correa; Poyrazoglu, Sukran; de Vries, Liat; Flück, Christa E.; Guran, Tulay; Bugrul, Fuat; Güven, Ayla; Iotova, Violeta; Koehler, Birgit; ... (2021). Surgical Practice in Girls with Congenital Adrenal Hyperplasia: An International Registry Study. Sexual development, 15(4), pp. 229-235. Karger 10.1159/000517055 Hebenstreit, D, Faisal Ahmed, S, Krone, N, Krall, C, Bryce, J, Alvi, S, Ortolano, R, Lima, M, Birkebaek, N, Bonfig, W, Van Der Grinten, H C, Costa, E C, Poyrazoglu, S, De Vries, L, Flück, C E, Guran, T, Bugrul, F, Güven, A, Iotova, V, Koehler, B, Schröder, J T, Konrad, D, Gevers, E, Krone, R, Milenkovic, T, Vieites, A, Ross, R, Cuccaro, R T, Hughes, I, Acerini, C & Springer, A 2021, ' Surgical Practice in Girls with Congenital Adrenal Hyperplasia : An International Registry Study ', Sexual Development, vol. 15, no. 4, pp. 229-235 . https://doi.org/10.1159/000517055 |
| Popis: | In this article international trends in surgical practice in girls with congenital adrenal hyperplasia (CAH) are evaluated. All cases that had been classified in the I-CAH/I-DSD registry as 46,XX CAH and who were born prior to 2017 were identified. Centers were approached to obtain information on surgical decision making. Of the 330 included participants, 208 (63.0%) presented within the first month of life, and 326 (98.8%) cases were assigned female. Genital surgery had been performed in 250 (75.8%). A total of 64.3, 89.2, and 96.8% of cases residing in Europe, South America and Asia, respectively, had at least one surgery. In a logistic regression model for the probability of surgery before the second birthday (early surgery) over time an increase of probability for early vaginal surgery could be identified, but not for clitoral surgery or both surgeries combined. Genitoplasty in girls with CAH remains controversial. This large international study provides a snapshot of current practice and reveals geographical and temporal differences. Fewer surgeries were reported for Europe, and there seems to be a significant trend towards aiming for vaginal surgery within the first 2 years of life. |
| Databáze: | OpenAIRE |
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