The microRNA landscape of cutaneous squamous cell carcinoma
| Autor: | Armando Flores-de la Torre, Zelmira Lazarova, Argelia López-Luna, Edit Olasz, Luis Steven Servín-González, José Luis Muñoz-Carrillo, Kathryn Konicke |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Cutaneous squamous cell carcinoma Skin Neoplasms 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery microRNA medicine Carcinoma Biomarkers Tumor Animals Humans Pharmacology business.industry Incidence (epidemiology) Cancer medicine.disease Prognosis MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Biomarker (medicine) Personalized medicine Skin cancer business |
| Zdroj: | Drug discovery today. 23(4) |
| ISSN: | 1878-5832 |
| Popis: | Cutaneous squamous cell carcinoma (cSCC) is a keratinocyte-derived skin tumor. It is the second-most-common cancer affecting the Caucasian population and is responsible for >20% of all skin-cancer-related deaths. The estimated incidence of non-melanoma skin cancer in the USA is >1000000 cases per year, of which roughly 20-30% are squamous cell carcinoma. To better understand and treat this challenging cancer, current research focuses on development of novel strategies to improve the understanding of tumor biogenesis on an individual basis. microRNAs are becoming important biomarkers in the diagnosis, prognosis and treatment of cSCC. This review describes the current knowledge on miRNA expression in cSCC and its role as a biomarker for personalized medicine. |
| Databáze: | OpenAIRE |
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